Small Molecule R1498 as a Well-Tolerated and Orally Active Kinase Inhibitor for Hepatocellular Carcinoma and Gastric Cancer Treatment via Targeting Angiogenesis and Mitosis Pathways

• Chao Zhang,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Xihan Wu,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Meifang Zhang,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Liangcheng Zhu,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Rong Zhao,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Danqing Xu,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Zhaohu Lin,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Chungen Liang,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Taiping Chen,

  Affiliation Crown Bioscience Inc. Beijing, China

  ⨯
• Li Chen,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Yi Ren,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Joe Zhang,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Ning Qin,

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯
• Xiongwen Zhang

  * E-mail: xwzhang@sat.ecnu.edu.cn

  Affiliation Roche Research and Early Development China, Shanghai, China

  ⨯