Osteoprotegerin Inhibits Aortic Valve Calcification and Preserves Valve Function in Hypercholesterolemic Mice

Robert M. Weiss; Donald D. Lund; Yi Chu; Robert M. Brooks; Kathy A. Zimmerman; Ramzi El Accaoui; Melissa K. Davis; Georges P. Hajj; M. Bridget Zimmerman; Donald D. Heistad

doi:10.1371/journal.pone.0065201

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Open Access

Peer-reviewed

Research Article

Osteoprotegerin Inhibits Aortic Valve Calcification and Preserves Valve Function in Hypercholesterolemic Mice

Robert M. Weiss ,

* E-mail: robert-weiss@uiowa.edu

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Donald D. Lund,

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Yi Chu,

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Robert M. Brooks,

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Kathy A. Zimmerman,

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Ramzi El Accaoui,

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Melissa K. Davis,

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
Georges P. Hajj,

Affiliation Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯
M. Bridget Zimmerman,

Affiliation Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, United States of America
⨯
Donald D. Heistad

Affiliations Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America, Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
⨯

Osteoprotegerin Inhibits Aortic Valve Calcification and Preserves Valve Function in Hypercholesterolemic Mice

Robert M. Weiss,
Donald D. Lund,
Yi Chu,
Robert M. Brooks,
Kathy A. Zimmerman,
Ramzi El Accaoui,
Melissa K. Davis,
Georges P. Hajj,
M. Bridget Zimmerman,
Donald D. Heistad

Published: June 6, 2013
https://doi.org/10.1371/journal.pone.0065201

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Calcification
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