Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells

Hélène Bugaut; Mélanie Bruchard; Hélène Berger; Valentin Derangère; Ludivine Odoul; Romain Euvrard; Sylvain Ladoire; Fanny Chalmin; Frédérique Végran; Cédric Rébé; Lionel Apetoh; François Ghiringhelli; Grégoire Mignot

doi:10.1371/journal.pone.0065181

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Research Article

Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells

Hélène Bugaut,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
Mélanie Bruchard,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
Hélène Berger,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
Valentin Derangère,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
Ludivine Odoul,

Affiliation University of Bern, Institute of Pathology, Bern, Switzerland
⨯
Romain Euvrard,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
Sylvain Ladoire,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France, Centre Georges François Leclerc, Dijon, France
⨯
Fanny Chalmin,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
Frédérique Végran,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
Cédric Rébé,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France, Centre Georges François Leclerc, Dijon, France
⨯
Lionel Apetoh,

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯
François Ghiringhelli ,

Contributed equally to this work with: François Ghiringhelli, Grégoire Mignot

* E-mail: fghiringhelli@cgfl.fr (FG); gregoire.mignot@free.fr (GM)

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France, Centre Georges François Leclerc, Dijon, France
⨯
Grégoire Mignot

Contributed equally to this work with: François Ghiringhelli, Grégoire Mignot

* E-mail: fghiringhelli@cgfl.fr (FG); gregoire.mignot@free.fr (GM)

Affiliations INSERM, U866, Dijon, France, INSERM AVENIR Team, Dijon, France, Faculté de Médecine, Université de Bourgogne, Dijon, France
⨯

Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells

Hélène Bugaut,
Mélanie Bruchard,
Hélène Berger,
Valentin Derangère,
Ludivine Odoul,
Romain Euvrard,
Sylvain Ladoire,
Fanny Chalmin,
Frédérique Végran,
Cédric Rébé

Published: June 7, 2013
https://doi.org/10.1371/journal.pone.0065181

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