3-Oxoacyl-ACP Reductase from Schistosoma japonicum: Integrated In Silico-In Vitro Strategy for Discovering Antischistosomal Lead Compounds

Jian Liu; Dave Dyer; Jipeng Wang; Shuqi Wang; Xiaofeng Du; Bin Xu; Haobing Zhang; Xiaoning Wang; Wei Hu

doi:10.1371/journal.pone.0064984

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Open Access

Peer-reviewed

Research Article

3-Oxoacyl-ACP Reductase from Schistosoma japonicum: Integrated In Silico-In Vitro Strategy for Discovering Antischistosomal Lead Compounds

Jian Liu,

Affiliations State Key Laboratory of Genetic Engineering, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China, Key Laboratory of Parasite and Vector Biology of Ministry of Public Health, Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
⨯
Dave Dyer,

Affiliation Department of Entomology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
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Jipeng Wang,

Affiliation State Key Laboratory of Genetic Engineering, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
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Shuqi Wang,

Affiliation State Key Laboratory of Genetic Engineering, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
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Xiaofeng Du,

Affiliation State Key Laboratory of Genetic Engineering, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
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Bin Xu,

Affiliation Key Laboratory of Parasite and Vector Biology of Ministry of Public Health, Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
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Haobing Zhang,

Affiliation Key Laboratory of Parasite and Vector Biology of Ministry of Public Health, Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
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Xiaoning Wang,

Affiliation State Key Laboratory of Genetic Engineering, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China
⨯
Wei Hu

* E-mail: huwwyz@163.com

Affiliations State Key Laboratory of Genetic Engineering, Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai, China, Key Laboratory of Parasite and Vector Biology of Ministry of Public Health, Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
⨯

3-Oxoacyl-ACP Reductase from Schistosoma japonicum: Integrated In Silico-In Vitro Strategy for Discovering Antischistosomal Lead Compounds

Jian Liu,
Dave Dyer,
Jipeng Wang,
Shuqi Wang,
Xiaofeng Du,
Bin Xu,
Haobing Zhang,
Xiaoning Wang,
Wei Hu

Published: June 7, 2013
https://doi.org/10.1371/journal.pone.0064984

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