Is Dynamic Autocrine Insulin Signaling Possible? A Mathematical Model Predicts Picomolar Concentrations of Extracellular Monomeric Insulin within Human Pancreatic Islets

Open Access

Peer-reviewed

Research Article

Minghu Wang,

Affiliation Department of Mathematics, University of Louisville, Louisville, Kentucky, United States of America
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Jiaxu Li ,

* E-mail: jiaxu.li@louisville.edu (JL); jimjohn@mail.ubc.ca (JDJ)

Affiliation Department of Mathematics, University of Louisville, Louisville, Kentucky, United States of America
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Gareth E. Lim,

Affiliation Department of Cellular and Physiological Sciences and Department of Surgery, University of British Columbia, Vancouver, BC, Canada
⨯
James D. Johnson

* E-mail: jiaxu.li@louisville.edu (JL); jimjohn@mail.ubc.ca (JDJ)

Affiliation Department of Cellular and Physiological Sciences and Department of Surgery, University of British Columbia, Vancouver, BC, Canada
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Insulin
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Glucose
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Monomers
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Dimers
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Insulin signaling
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Blood flow
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Insulin secretion
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Pancreas
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