A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

Manuela Cervelli; Gabriella Bellavia; Marcello D'Amelio; Virve Cavallucci; Sandra Moreno; Joachim Berger; Roberta Nardacci; Manuela Marcoli; Guido Maura; Mauro Piacentini; Roberto Amendola; Francesco Cecconi; Paolo Mariottini

doi:10.1371/journal.pone.0064810

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Peer-reviewed

Research Article

A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

Manuela Cervelli ,

* E-mail: cervelli@uniroma3.it

Affiliation Dipartimento di Biologia, Università “Roma Tre,” Rome, Italy
⨯
Gabriella Bellavia,

Affiliation Dipartimento di Biologia, Università “Roma Tre,” Rome, Italy
⨯
Marcello D'Amelio,

Affiliation Laboratory of Molecular Neuroembryology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy
⨯
Virve Cavallucci,

Affiliation Laboratory of Molecular Neuroembryology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy
⨯
Sandra Moreno,

Affiliation Dipartimento di Biologia, Università “Roma Tre,” Rome, Italy
⨯
Joachim Berger,

Affiliation Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia
⨯
Roberta Nardacci,

Affiliation Istituto Nazionale per le Malattie Infettive, IRCCS “L. Spallanzani,” Rome, Italy
⨯
Manuela Marcoli,

Affiliation Dipartimento di Farmacia, Sez. Farmacologia e Tossicologia, Centro di Eccellenza per la Ricerca Biomedica CEBR, Università di Genova, Genoa, Italy
⨯
Guido Maura,

Affiliation Dipartimento di Farmacia, Sez. Farmacologia e Tossicologia, Centro di Eccellenza per la Ricerca Biomedica CEBR, Università di Genova, Genoa, Italy
⨯
Mauro Piacentini,

Affiliation Istituto Nazionale per le Malattie Infettive, IRCCS “L. Spallanzani,” Rome, Italy
⨯
Roberto Amendola,

Affiliation Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile (ENEA), Il Centro Ricerche Casaccia, Sezione Tossicologia e Scienze Biomediche (BAS-BIOTECMED), Rome, Italy
⨯
Francesco Cecconi,

Affiliation Laboratory of Molecular Neuroembryology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, Italy
⨯
Paolo Mariottini

Affiliation Dipartimento di Biologia, Università “Roma Tre,” Rome, Italy
⨯

A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

Manuela Cervelli,
Gabriella Bellavia,
Marcello D'Amelio,
Virve Cavallucci,
Sandra Moreno,
Joachim Berger,
Roberta Nardacci,
Manuela Marcoli,
Guido Maura,
Mauro Piacentini

Published: June 19, 2013
https://doi.org/10.1371/journal.pone.0064810

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Genetically modified animals
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Neocortex
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Immunohistochemical analysis
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