Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways

• Chien-Chih Chiu,

  Affiliation Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Jo-Wen Haung,

  Affiliation Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Fang-Rong Chang,

  Affiliation Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Kuang-Jing Huang,

  Affiliation Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Hsuan-Min Huang,

  Affiliation Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Hurng-Wern Huang,

  Affiliation Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan

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• Chon-Kit Chou,

  Affiliation Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan

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• Yang-Chang Wu ,

  * E-mail: yachwu@mail.cmu.edu.tw (Y-CW); changhw@kmu.edu.tw (H-WC)

  Affiliations Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Department of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, Natural Medicinal Products Research Center and Center of Molecular Cancer, China Medical University Hospital, Taichung, Taiwan

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• Hsueh-Wei Chang

  * E-mail: yachwu@mail.cmu.edu.tw (Y-CW); changhw@kmu.edu.tw (H-WC)

  Affiliations Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan, Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

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