Elevated Levels of CD4+CD25+FoxP3+ T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction

Xinjuan Liu; Na Gao; Mengtao Li; Dong Xu; Yong Hou; Qian Wang; Guohua Zhang; Qiuning Sun; Henghui Zhang; Xiaofeng Zeng

doi:10.1371/journal.pone.0064531

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Open Access

Peer-reviewed

Research Article

Elevated Levels of CD4⁺CD25⁺FoxP3⁺ T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction

Xinjuan Liu ,

Contributed equally to this work with: Xinjuan Liu, Na Gao

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Na Gao ,

Contributed equally to this work with: Xinjuan Liu, Na Gao

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Mengtao Li,

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Dong Xu,

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Yong Hou,

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Qian Wang,

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Guohua Zhang,

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Qiuning Sun,

Affiliation Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯
Henghui Zhang ,

* E-mail: zengxfpumc@yahoo.cn (XZ); zhhbao@163.com (HZ)

Affiliation Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing, China
⨯
Xiaofeng Zeng

* E-mail: zengxfpumc@yahoo.cn (XZ); zhhbao@163.com (HZ)

Affiliation Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
⨯

Elevated Levels of CD4⁺CD25⁺FoxP3⁺ T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction

Xinjuan Liu,
Na Gao,
Mengtao Li,
Dong Xu,
Yong Hou,
Qian Wang,
Guohua Zhang,
Qiuning Sun,
Henghui Zhang,
Xiaofeng Zeng

Published: June 11, 2013
https://doi.org/10.1371/journal.pone.0064531

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