The Prevalence and Phenotype of Activated Microglia/Macrophages within the Spinal Cord of the Hyperostotic Mouse (twy/twy) Changes in Response to Chronic Progressive Spinal Cord Compression: Implications for Human Cervical Compressive Myelopathy

Takayuki Hirai; Kenzo Uchida; Hideaki Nakajima; Alexander Rodriguez Guerrero; Naoto Takeura; Shuji Watanabe; Daisuke Sugita; Ai Yoshida; William E. B. Johnson; Hisatoshi Baba

doi:10.1371/journal.pone.0064528

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Open Access

Peer-reviewed

Research Article

The Prevalence and Phenotype of Activated Microglia/Macrophages within the Spinal Cord of the Hyperostotic Mouse (twy/twy) Changes in Response to Chronic Progressive Spinal Cord Compression: Implications for Human Cervical Compressive Myelopathy

Takayuki Hirai,

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
Kenzo Uchida ,

* E-mail: kuchida@u-fukui.ac.jp

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
Hideaki Nakajima,

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
Alexander Rodriguez Guerrero,

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
Naoto Takeura,

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
Shuji Watanabe,

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
Daisuke Sugita,

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
Ai Yoshida,

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯
William E. B. Johnson,

Affiliation Life & Health Sciences, Aston University, Aston Triangle, Birmingham, United Kingdom
⨯
Hisatoshi Baba

Affiliation Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
⨯

The Prevalence and Phenotype of Activated Microglia/Macrophages within the Spinal Cord of the Hyperostotic Mouse (twy/twy) Changes in Response to Chronic Progressive Spinal Cord Compression: Implications for Human Cervical Compressive Myelopathy

Takayuki Hirai,
Kenzo Uchida,
Hideaki Nakajima,
Alexander Rodriguez Guerrero,
Naoto Takeura,
Shuji Watanabe,
Daisuke Sugita,
Ai Yoshida,
William E. B. Johnson,
Hisatoshi Baba

Published: May 24, 2013
https://doi.org/10.1371/journal.pone.0064528

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