Systemic Down-Regulation of Delta-9 Desaturase Promotes Muscle Oxidative Metabolism and Accelerates Muscle Function Recovery following Nerve Injury

Ghulam Hussain; Florent Schmitt; Alexandre Henriques; Thiebault Lequeu; Frederique Rene; Françoise Bindler; Sylvie Dirrig-Grosch; Hugues Oudart; Lavinia Palamiuc; Marie-Helene Metz-Boutigue; Luc Dupuis; Eric Marchioni; Jose-Luis Gonzalez De Aguilar; Jean-Philippe Loeffler

doi:10.1371/journal.pone.0064525

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Systemic Down-Regulation of Delta-9 Desaturase Promotes Muscle Oxidative Metabolism and Accelerates Muscle Function Recovery following Nerve Injury

Ghulam Hussain ,

Contributed equally to this work with: Ghulam Hussain, Florent Schmitt

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Florent Schmitt ,

Contributed equally to this work with: Ghulam Hussain, Florent Schmitt

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Alexandre Henriques,

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Thiebault Lequeu,

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Frederique Rene,

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Françoise Bindler,

Affiliation CNRS, UMR7178, Institut Pluridisciplinaire Hubert Curien, Equipe de Chimie Analytique des Molécules Bioactives, Illkirch, France
⨯
Sylvie Dirrig-Grosch,

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Hugues Oudart,

Affiliation CNRS, UPR9010, Institut Pluridisciplinaire Hubert Curien, Département d'Ecologie, Physiologie et Ethologie, Strasbourg, France
⨯
Lavinia Palamiuc,

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Marie-Helene Metz-Boutigue,

Affiliation INSERM, U977, Laboratoire des Biomatériaux et Ingéniérie Tissulaire, Strasbourg, France
⨯
Luc Dupuis,

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Eric Marchioni,

Affiliation CNRS, UMR7178, Institut Pluridisciplinaire Hubert Curien, Equipe de Chimie Analytique des Molécules Bioactives, Illkirch, France
⨯
Jose-Luis Gonzalez De Aguilar ,

* E-mail: gonzalez@unistra.fr (JLGDA); loeffler@unistra.fr (JPL)

¶JLGDA and JPL are joint senior authors on this work.

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯
Jean-Philippe Loeffler

* E-mail: gonzalez@unistra.fr (JLGDA); loeffler@unistra.fr (JPL)

¶JLGDA and JPL are joint senior authors on this work.

Affiliations INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, UMRS1118, Strasbourg, France
⨯

Systemic Down-Regulation of Delta-9 Desaturase Promotes Muscle Oxidative Metabolism and Accelerates Muscle Function Recovery following Nerve Injury

Ghulam Hussain,
Florent Schmitt,
Alexandre Henriques,
Thiebault Lequeu,
Frederique Rene,
Françoise Bindler,
Sylvie Dirrig-Grosch,
Hugues Oudart,
Lavinia Palamiuc,
Marie-Helene Metz-Boutigue

Published: June 13, 2013
https://doi.org/10.1371/journal.pone.0064525

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