Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

Yutaka Takebe; Carrie J. Saucedo; Garry Lund; Rie Uenishi; Saiki Hase; Takayo Tsuchiura; Norman Kneteman; Koreen Ramessar; D. Lorne J. Tyrrell; Masayuki Shirakura; Takaji Wakita; James B. McMahon; Barry R. O'Keefe

doi:10.1371/journal.pone.0064449

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Open Access

Peer-reviewed

Research Article

Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

Yutaka Takebe,

Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Carrie J. Saucedo,

Affiliation Molecular Targets Laboratory, SAIC-Frederick, Frederick, Maryland, United States of America
⨯
Garry Lund,

Affiliation KMT Hepatech, Edmonton, Alberta, Canada
⨯
Rie Uenishi,

Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Saiki Hase,

Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Takayo Tsuchiura,

Affiliation AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Norman Kneteman,

Affiliation KMT Hepatech, Edmonton, Alberta, Canada
⨯
Koreen Ramessar,

Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
D. Lorne J. Tyrrell,

Affiliation KMT Hepatech, Edmonton, Alberta, Canada
⨯
Masayuki Shirakura,

Current address: Influenza Research Center, National Institute of Infectious Diseases, Tokyo, Japan

Affiliation Virology II, National Institute of Infectious Diseases, Tokyo, Japan
⨯
Takaji Wakita,

Affiliation Virology II, National Institute of Infectious Diseases, Tokyo, Japan
⨯
James B. McMahon,

Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Barry R. O'Keefe

* E-mail: okeefeba@mail.nih.gov

Affiliation Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America
⨯

Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

Yutaka Takebe,
Carrie J. Saucedo,
Garry Lund,
Rie Uenishi,
Saiki Hase,
Takayo Tsuchiura,
Norman Kneteman,
Koreen Ramessar,
D. Lorne J. Tyrrell,
Masayuki Shirakura

Published: May 21, 2013
https://doi.org/10.1371/journal.pone.0064449

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