Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rgnull Mice

Jeannette Cany; Anniek B. van der Waart; Marleen Tordoir; Gerben M. Franssen; Basav N. Hangalapura; Jolanda de Vries; Otto Boerman; Nicolaas Schaap; Robbert van der Voort; Jan Spanholtz; Harry Dolstra

doi:10.1371/journal.pone.0064384

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Peer-reviewed

Research Article

Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rg^null Mice

Jeannette Cany,

Affiliation Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands
⨯
Anniek B. van der Waart,

Affiliation Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands
⨯
Marleen Tordoir,

Affiliations Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands, Glycostem Therapeutics, Nijmegen, The Netherlands
⨯
Gerben M. Franssen,

Affiliation Department of Nuclear Medicine, RUNMC, Nijmegen, The Netherlands
⨯
Basav N. Hangalapura,

Affiliation Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands
⨯
Jolanda de Vries,

Affiliation Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
⨯
Otto Boerman,

Affiliation Department of Nuclear Medicine, RUNMC, Nijmegen, The Netherlands
⨯
Nicolaas Schaap,

Affiliation Department of Hematology, RUNMC, Nijmegen, The Netherlands
⨯
Robbert van der Voort,

Affiliation Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands
⨯
Jan Spanholtz,

Affiliations Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands, Glycostem Therapeutics, Nijmegen, The Netherlands
⨯
Harry Dolstra

* E-mail: H.Dolstra@labgk.umcn.nl

Affiliation Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands
⨯

Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rg^null Mice

Jeannette Cany,
Anniek B. van der Waart,
Marleen Tordoir,
Gerben M. Franssen,
Basav N. Hangalapura,
Jolanda de Vries,
Otto Boerman,
Nicolaas Schaap,
Robbert van der Voort,
Jan Spanholtz

Published: June 5, 2013
https://doi.org/10.1371/journal.pone.0064384

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