Imputation of Variants from the 1000 Genomes Project Modestly Improves Known Associations and Can Identify Low-frequency Variant - Phenotype Associations Undetected by HapMap Based Imputation

• Andrew R. Wood,

  Affiliation Genetics of Complex traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom

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• John R. B. Perry,

  Affiliations Genetics of Complex traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• Toshiko Tanaka,

  Affiliation Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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• Dena G. Hernandez,

  Affiliations Laboratory of Neurogenetics, National Institute of Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Laboratories, Institute of Neurology, UCL, London, United Kingdom

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• Hou-Feng Zheng,

  Affiliation Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

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• David Melzer,

  Affiliation Epidemiology and Public Health, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom

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• J. Raphael Gibbs,

  Affiliations Laboratory of Neurogenetics, National Institute of Aging, Bethesda, Maryland, United States of America, Department of Molecular Neuroscience and Reta Lila Laboratories, Institute of Neurology, UCL, London, United Kingdom

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• Michael A. Nalls,

  Affiliation Laboratory of Neurogenetics, National Institute of Aging, Bethesda, Maryland, United States of America

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• Michael N. Weedon,

  Affiliation Genetics of Complex traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom

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• Tim D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

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• J. Brent Richards,

  Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, Jewish General Hospital, McGill University, Montreal, Quebec, Canada

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• Stefania Bandinelli,

  Affiliations Tuscany Regional Health Agency, Florence, Italy, I.O.T. and Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy, Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy

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• Luigi Ferrucci,

  Affiliation Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America

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• Andrew B. Singleton,

  Affiliation Laboratory of Neurogenetics, National Institute of Aging, Bethesda, Maryland, United States of America

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• Timothy M. Frayling

  * E-mail: tim.frayling@pms.ac.uk

  Affiliation Genetics of Complex traits, Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom

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