Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

François Huaux; Sabrina Noel; Barbara Dhooghe; Nadtha Panin; Sandra Lo Re; Dominique Lison; Pierre Wallemacq; Etienne Marbaix; Bob J. Scholte; Patrick Lebecque; Teresinha Leal

doi:10.1371/journal.pone.0064341

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Peer-reviewed

Research Article

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

François Huaux ,

Contributed equally to this work with: François Huaux, Sabrina Noel

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
⨯
Sabrina Noel ,

Contributed equally to this work with: François Huaux, Sabrina Noel

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
⨯
Barbara Dhooghe,

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
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Nadtha Panin,

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
⨯
Sandra Lo Re,

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
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Dominique Lison,

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
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Pierre Wallemacq,

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
⨯
Etienne Marbaix,

Affiliation de Duve Institute, Université Catholique de Louvain (UCL), Brussels, Belgium
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Bob J. Scholte,

Affiliation Cell Biology, Erasmus MC, Rotterdam, The Netherlands
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Patrick Lebecque,

Affiliation Pediatric Pulmonology, Cliniques Saint Luc, Université Catholique de Louvain (UCL), Brussels, Belgium
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Teresinha Leal

* E-mail: teresinha.leal@uclouvain.be

Affiliation Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCL), Brussels, Belgium
⨯

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

François Huaux,
Sabrina Noel,
Barbara Dhooghe,
Nadtha Panin,
Sandra Lo Re,
Dominique Lison,
Pierre Wallemacq,
Etienne Marbaix,
Bob J. Scholte,
Patrick Lebecque

Published: May 29, 2013
https://doi.org/10.1371/journal.pone.0064341

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Fibroblasts
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Mouse models
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Inflammation
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Cystic fibrosis
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Cell differentiation
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Fibrosis
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Homozygosity
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Growth factors
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