Single Nucleotide Polymorphisms in Pathogen Recognition Receptor Genes Are Associated with Susceptibility to Meningococcal Meningitis in a Pediatric Cohort

Gijs Th J. van Well; Marieke S. Sanders; Sander Ouburg; Vinod Kumar; A. Marceline van Furth; Servaas A. Morré

doi:10.1371/journal.pone.0064252

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Peer-reviewed

Research Article

Single Nucleotide Polymorphisms in Pathogen Recognition Receptor Genes Are Associated with Susceptibility to Meningococcal Meningitis in a Pediatric Cohort

Gijs Th J. van Well ,

Contributed equally to this work with: Gijs Th J. van Well, Marieke S. Sanders

Affiliations Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands, Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Marieke S. Sanders ,

Contributed equally to this work with: Gijs Th J. van Well, Marieke S. Sanders

Affiliations Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands, Department of Medical Microbiology and Infection Control, Laboratory for Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands
⨯
Sander Ouburg,

Affiliation Department of Medical Microbiology and Infection Control, Laboratory for Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands
⨯
Vinod Kumar,

Affiliation Department of Human Genetics, University Medical Center Groningen, Groningen, The Netherlands
⨯
A. Marceline van Furth,

Affiliation Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Servaas A. Morré

* E-mail: samorretravel@yahoo.co.uk

Affiliations Department of Medical Microbiology and Infection Control, Laboratory for Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands, Institute of Public Health Genomics, Department of Genetics and Cell Biology, Research Institute: School for Oncology & Developmental Biology, Faculty of Health, Medicine & Life Sciences, Maastricht University Medical Center, Maastricht, The Netherlands
⨯

Single Nucleotide Polymorphisms in Pathogen Recognition Receptor Genes Are Associated with Susceptibility to Meningococcal Meningitis in a Pediatric Cohort

Gijs Th J. van Well,
Marieke S. Sanders,
Sander Ouburg,
Vinod Kumar,
A. Marceline van Furth,
Servaas A. Morré

Published: May 14, 2013
https://doi.org/10.1371/journal.pone.0064252

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Single nucleotide polymorphisms
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Toll-like receptors
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Genetic predisposition
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Meningitis
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Variant genotypes
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Bacterial meningitis
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Alleles
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Central nervous system
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