Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor

Open Access

Peer-reviewed

Research Article

Inna Biela ,

Contributed equally to this work with: Inna Biela, Naomi Tidten-Luksch

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Naomi Tidten-Luksch ,

Contributed equally to this work with: Inna Biela, Naomi Tidten-Luksch

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Florian Immekus,

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Serghei Glinca,

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Tran Xuan Phong Nguyen,

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Hans-Dieter Gerber,

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Andreas Heine,

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Gerhard Klebe,

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯
Klaus Reuter

* E-mail: reuterk@staff.uni-marburg.de

Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
⨯

Reader Comments (0)

Guanine
Is the Subject Area "Guanine" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Transfer RNA
Is the Subject Area "Transfer RNA" applicable to this article?

Thanks for your feedback.
Electron density
Is the Subject Area "Electron density" applicable to this article?

Thanks for your feedback.
Crystal structure refinement
Is the Subject Area "Crystal structure refinement" applicable to this article?

Thanks for your feedback.
Valine
Is the Subject Area "Valine" applicable to this article?

Thanks for your feedback.
Carbon
Is the Subject Area "Carbon" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.