Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding

Paola E. J. van der Meijden; Annemieke C. Bouman; Marion A. H. Feijge; René van Oerle; Henri M. H. Spronk; Karly Hamulyák; Arina J. ten Cate-Hoek; Hugo ten Cate; Johan W. M. Heemskerk

doi:10.1371/journal.pone.0064112

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Open Access

Peer-reviewed

Research Article

Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding

Paola E. J. van der Meijden ,

* E-mail: p.vandermeijden@maastrichtuniversity.nl

Affiliations Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands, Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Annemieke C. Bouman,

Affiliation Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Marion A. H. Feijge,

Affiliation Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
René van Oerle,

Affiliation Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Henri M. H. Spronk,

Affiliation Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Karly Hamulyák,

Affiliation Haemostasis Laboratory, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Arina J. ten Cate-Hoek,

Affiliation Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Hugo ten Cate,

Affiliation Laboratory for Clinical Thrombosis and Haemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Johan W. M. Heemskerk

Affiliation Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
⨯

Platelet Dysfunction in Thrombosis Patients Treated with Vitamin K Antagonists and Recurrent Bleeding

Paola E. J. van der Meijden,
Annemieke C. Bouman,
Marion A. H. Feijge,
René van Oerle,
Henri M. H. Spronk,
Karly Hamulyák,
Arina J. ten Cate-Hoek,
Hugo ten Cate,
Johan W. M. Heemskerk

Published: May 28, 2013
https://doi.org/10.1371/journal.pone.0064112

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Hemorrhage
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Platelets
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Anticoagulant therapy
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Blood plasma
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Platelet activation
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Thrombosis
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