Retinal Pigmented Epithelial Cells Cytotoxicity and Apoptosis through Activation of the Mitochondrial Intrinsic Pathway: Role Of Indocyanine Green, Brilliant Blue and Implications for Chromovitrectomy

Fernando M. Penha; Marianne Pons; Elaine Fiod Costa; Nilana Meza Tenório Barros; Eduardo B. Rodrigues; Emmerson Badaró Cardoso; Eduardo Dib; Mauricio Maia; Maria E. Marin-Castaño; Michel Eid Farah

doi:10.1371/journal.pone.0064094

Loading metrics

Open Access

Peer-reviewed

Research Article

Retinal Pigmented Epithelial Cells Cytotoxicity and Apoptosis through Activation of the Mitochondrial Intrinsic Pathway: Role Of Indocyanine Green, Brilliant Blue and Implications for Chromovitrectomy

Fernando M. Penha ,

* E-mail: penhaepm@yahoo.com.br (FMP); mcastano@med.miami.edu (MEMC)

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯
Marianne Pons,

Affiliation Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
⨯
Elaine Fiod Costa,

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯
Nilana Meza Tenório Barros,

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯
Eduardo B. Rodrigues,

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯
Emmerson Badaró Cardoso,

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯
Eduardo Dib,

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯
Mauricio Maia,

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯
Maria E. Marin-Castaño ,

* E-mail: penhaepm@yahoo.com.br (FMP); mcastano@med.miami.edu (MEMC)

Affiliation Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
⨯
Michel Eid Farah

Affiliation Departamento de Oftalmologia, Instituto da Visão (IPEPO), Universidade Federal de São Paulo, São Paulo, SP, Brazil
⨯

Retinal Pigmented Epithelial Cells Cytotoxicity and Apoptosis through Activation of the Mitochondrial Intrinsic Pathway: Role Of Indocyanine Green, Brilliant Blue and Implications for Chromovitrectomy

Fernando M. Penha,
Marianne Pons,
Elaine Fiod Costa,
Nilana Meza Tenório Barros,
Eduardo B. Rodrigues,
Emmerson Badaró Cardoso,
Eduardo Dib,
Mauricio Maia,
Maria E. Marin-Castaño,
Michel Eid Farah

Published: May 10, 2013
https://doi.org/10.1371/journal.pone.0064094

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Eyes
Is the Subject Area "Eyes" applicable to this article?

Thanks for your feedback.
Dyes
Is the Subject Area "Dyes" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Vitreoretinal surgery
Is the Subject Area "Vitreoretinal surgery" applicable to this article?

Thanks for your feedback.
MTS assay
Is the Subject Area "MTS assay" applicable to this article?

Thanks for your feedback.
Viable cell counting
Is the Subject Area "Viable cell counting" applicable to this article?

Thanks for your feedback.