Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products

• Nadine Bohni ,

  Contributed equally to this work with: Nadine Bohni, María Lorena Cordero-Maldonado

  Affiliation School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, Geneva, Switzerland

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• María Lorena Cordero-Maldonado ,

  Contributed equally to this work with: Nadine Bohni, María Lorena Cordero-Maldonado

  Affiliations Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium, Faculty of Chemistry Sciences, School of Biochemistry and Pharmacy, University of Cuenca, Cuenca, Ecuador

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• Jan Maes,

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Dany Siverio-Mota,

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Laurence Marcourt,

  Affiliation School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, Geneva, Switzerland

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• Sebastian Munck,

  Affiliation VIB Center for the Biology of Disease, University of Leuven, Leuven, Belgium

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• Appolinary R. Kamuhabwa,

  Affiliation Faculty of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

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• Mainen J. Moshi,

  Affiliation Faculty of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania

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• Camila V. Esguerra,

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Peter A. M. de Witte,

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Alexander D. Crawford ,

  * E-mail: alexander.crawford@pharm.kuleuven.be

  ¶These authors also contributed equally to this work.

  Affiliation Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium

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• Jean-Luc Wolfender

  ¶These authors also contributed equally to this work.

  Affiliation School of Pharmaceutical Sciences, EPGL, University of Geneva, University of Lausanne, Geneva, Switzerland

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