Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation

Olivier Cala; Marie-Hélène Remy; Valérie Guillet; Andreas Merdes; Lionel Mourey; Alain Milon; Georges Czaplicki

doi:10.1371/journal.pone.0063908

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Research Article

Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation

Olivier Cala,

Affiliations Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS – Université de Toulouse, UPS, Toulouse, France, Faculté des Sciences et de l’Ingénierie, Université de Toulouse, UPS, Toulouse, France
⨯
Marie-Hélène Remy,

Affiliations Centre de Biologie du Développement, CNRS, Toulouse, France, Faculté des Sciences et de l’Ingénierie, Université de Toulouse, UPS, Toulouse, France
⨯
Valérie Guillet,

Affiliations Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS – Université de Toulouse, UPS, Toulouse, France, Faculté des Sciences et de l’Ingénierie, Université de Toulouse, UPS, Toulouse, France
⨯
Andreas Merdes,

Affiliations Centre de Biologie du Développement, CNRS, Toulouse, France, Faculté des Sciences et de l’Ingénierie, Université de Toulouse, UPS, Toulouse, France
⨯
Lionel Mourey,

Affiliations Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS – Université de Toulouse, UPS, Toulouse, France, Faculté des Sciences et de l’Ingénierie, Université de Toulouse, UPS, Toulouse, France
⨯
Alain Milon,

Affiliations Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS – Université de Toulouse, UPS, Toulouse, France, Faculté des Sciences et de l’Ingénierie, Université de Toulouse, UPS, Toulouse, France
⨯
Georges Czaplicki

* E-mail: Georges.Czaplicki@ipbs.fr

Affiliations Institut de Pharmacologie et de Biologie Structurale, UMR 5089 CNRS – Université de Toulouse, UPS, Toulouse, France, Faculté des Sciences et de l’Ingénierie, Université de Toulouse, UPS, Toulouse, France
⨯

Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation

Olivier Cala,
Marie-Hélène Remy,
Valérie Guillet,
Andreas Merdes,
Lionel Mourey,
Alain Milon,
Georges Czaplicki

Published: May 15, 2013
https://doi.org/10.1371/journal.pone.0063908

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