Ursolic Acid Simultaneously Targets Multiple Signaling Pathways to Suppress Proliferation and Induce Apoptosis in Colon Cancer Cells

Jingshu Wang; Liqun Liu; Huijuan Qiu; Xiaohong Zhang; Wei Guo; Wangbing Chen; Yun Tian; Lingyi Fu; Dingbo Shi; Jianding Cheng; Wenlin Huang; Wuguo Deng

doi:10.1371/journal.pone.0063872

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Open Access

Peer-reviewed

Research Article

Ursolic Acid Simultaneously Targets Multiple Signaling Pathways to Suppress Proliferation and Induce Apoptosis in Colon Cancer Cells

Jingshu Wang ,

Contributed equally to this work with: Jingshu Wang, Liqun Liu, Huijuan Qiu

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Liqun Liu ,

Contributed equally to this work with: Jingshu Wang, Liqun Liu, Huijuan Qiu

Affiliation The First Affiliated Hospital-Huangpu Hospital, Sun Yat-Sen University, Guangzhou, China
⨯
Huijuan Qiu ,

Contributed equally to this work with: Jingshu Wang, Liqun Liu, Huijuan Qiu

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Xiaohong Zhang,

Affiliation Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China
⨯
Wei Guo,

Affiliation Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China
⨯
Wangbing Chen,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Yun Tian,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Lingyi Fu,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Dingbo Shi,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Jianding Cheng ,

* E-mail: dengwg@sysucc.org.cn (WD); huangwl@sysucc.org.cn (WH); jdcheng2001@yahoo.com.cn (JC)

Affiliation Department of Forensic Pathology, Sun Yat-Sen University Medical School, Guangzhou, China
⨯
Wenlin Huang ,

* E-mail: dengwg@sysucc.org.cn (WD); huangwl@sysucc.org.cn (WH); jdcheng2001@yahoo.com.cn (JC)

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China, State Key Laboratory of Targeted Drug for Tumors of Guangdong Province, Guangzhou Double Bioproduct Inc, Guangzhou, China
⨯
Wuguo Deng

* E-mail: dengwg@sysucc.org.cn (WD); huangwl@sysucc.org.cn (WH); jdcheng2001@yahoo.com.cn (JC)

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯

Ursolic Acid Simultaneously Targets Multiple Signaling Pathways to Suppress Proliferation and Induce Apoptosis in Colon Cancer Cells

Jingshu Wang,
Liqun Liu,
Huijuan Qiu,
Xiaohong Zhang,
Wei Guo,
Wangbing Chen,
Yun Tian,
Lingyi Fu,
Dingbo Shi,
Jianding Cheng

Published: May 30, 2013
https://doi.org/10.1371/journal.pone.0063872

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