High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound with Anti-Diabetic Efficacy in db/db Mice

Meng Zhang; Yang Feng; Jia Wang; Jianwei Zhao; Ting Li; Min He; Dehua Yang; Olivier Nosjean; Jean Boutin; Pierre Renard; Ming-Wei Wang

doi:10.1371/journal.pone.0063861

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Open Access

Peer-reviewed

Research Article

High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound with Anti-Diabetic Efficacy in db/db Mice

Meng Zhang,

Affiliation The National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Yang Feng,

Affiliation The National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Jia Wang,

Affiliation Chinese National Compound Library, Shanghai, China
⨯
Jianwei Zhao,

Affiliation Chinese National Compound Library, Shanghai, China
⨯
Ting Li,

Affiliation The National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Min He,

Affiliation Chinese National Compound Library, Shanghai, China
⨯
Dehua Yang,

Affiliation The National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
⨯
Olivier Nosjean,

Affiliation Les Laboratoires Servier, Neuilly-sur-Seine, France
⨯
Jean Boutin,

Affiliation Les Laboratoires Servier, Neuilly-sur-Seine, France
⨯
Pierre Renard,

Affiliation Les Laboratoires Servier, Neuilly-sur-Seine, France
⨯
Ming-Wei Wang

* E-mail: wangmw@mail.shcnc.ac.cn

Affiliations The National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, Chinese National Compound Library, Shanghai, China
⨯

High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound with Anti-Diabetic Efficacy in db/db Mice

Meng Zhang,
Yang Feng,
Jia Wang,
Jianwei Zhao,
Ting Li,
Min He,
Dehua Yang,
Olivier Nosjean,
Jean Boutin,
Pierre Renard

Published: May 21, 2013
https://doi.org/10.1371/journal.pone.0063861

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