Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury

Lingling Wu; Zhe Feng; Shaoyuan Cui; Kai Hou; Li Tang; Jianhui Zhou; Guangyan Cai; Yuansheng Xie; Quan Hong; Bo Fu; Xiangmei Chen

doi:10.1371/journal.pone.0063799

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Open Access

Peer-reviewed

Research Article

Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury

Lingling Wu,

Affiliations State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China, Medical College, NanKai University, Tianjin, China
⨯
Zhe Feng ,

* E-mail: xmchen301@126.com (XC); zhezhe_4025@126.com (ZF)

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Shaoyuan Cui,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Kai Hou,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Li Tang,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Jianhui Zhou,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Guangyan Cai,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Yuansheng Xie,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Quan Hong,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Bo Fu,

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯
Xiangmei Chen

* E-mail: xmchen301@126.com (XC); zhezhe_4025@126.com (ZF)

Affiliation State Key Laboratory of Kidney Diseases, Department of Nephrology, PLA General Hospital and Military Medical Postgraduate College, Beijing, China
⨯

Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury

Lingling Wu,
Zhe Feng,
Shaoyuan Cui,
Kai Hou,
Li Tang,
Jianhui Zhou,
Guangyan Cai,
Yuansheng Xie,
Quan Hong,
Bo Fu

Published: May 8, 2013
https://doi.org/10.1371/journal.pone.0063799

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