Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells

Open Access

Peer-reviewed

Research Article

Xing Chen ,

Contributed equally to this work with: Xing Chen, Yuping Du

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Yuping Du ,

Contributed equally to this work with: Xing Chen, Yuping Du

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Jing Nan,

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Xinxin Zhang,

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Xiaodong Qin,

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Yuxin Wang,

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Jianwen Hou,

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Qin Wang,

Affiliation School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China
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Jinbo Yang

* E-mail: yangjb@lzu.edu.cn

Affiliations School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People’s Republic of China, Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, United States of America
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STAT signaling
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Signal inhibition
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Phosphorylation
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Tyrosine kinases
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Colorectal cancer
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Drug screening
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JAK-STAT signaling cascade
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Prostate cancer
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