FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells

Shun X. Ren; Jin Shen; Alfred S. L. Cheng; Lan Lu; Ruby L. Y. Chan; Zhi J. Li; Xiao J. Wang; Clover C. M. Wong; Lin Zhang; Simon S. M. Ng; Franky L. Chan; Francis K. L. Chan; Jun Yu; Joseph J. Y. Sung; William K. K. Wu; Chi H. Cho

doi:10.1371/journal.pone.0063641

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Open Access

Peer-reviewed

Research Article

FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells

Shun X. Ren,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Jin Shen,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Alfred S. L. Cheng,

Affiliation Institute of Digestive Disease, Li Ka Shing Institute of Health and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
⨯
Lan Lu,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Ruby L. Y. Chan,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Zhi J. Li,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Xiao J. Wang,

Affiliation Institute of Digestive Disease, Li Ka Shing Institute of Health and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
⨯
Clover C. M. Wong,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Lin Zhang,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Simon S. M. Ng,

Affiliation Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China
⨯
Franky L. Chan,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
Francis K. L. Chan,

Affiliation Institute of Digestive Disease, Li Ka Shing Institute of Health and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
⨯
Jun Yu,

Affiliation Institute of Digestive Disease, Li Ka Shing Institute of Health and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
⨯
Joseph J. Y. Sung,

Affiliation Institute of Digestive Disease, Li Ka Shing Institute of Health and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
⨯
William K. K. Wu ,

* E-mail: wukakei@cuhk.edu.hk

Affiliation Institute of Digestive Disease, Li Ka Shing Institute of Health and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
⨯
[ ... ],
Chi H. Cho

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China
⨯
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FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells

Shun X. Ren,
Jin Shen,
Alfred S. L. Cheng,
Lan Lu,
Ruby L. Y. Chan,
Zhi J. Li,
Xiao J. Wang,
Clover C. M. Wong,
Lin Zhang,
Simon S. M. Ng

Published: May 20, 2013
https://doi.org/10.1371/journal.pone.0063641

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