IKBKE Phosphorylation and Inhibition of FOXO3a: A Mechanism of IKBKE Oncogenic Function

Open Access

Peer-reviewed

Research Article

Jian-Ping Guo ,

Contributed equally to this work with: Jian-Ping Guo, Wei Tian

Affiliations Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, China, Department of Molecular Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, United States of America
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Wei Tian ,

Contributed equally to this work with: Jian-Ping Guo, Wei Tian

Affiliations Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, China, Department of Molecular Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, United States of America
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Shaokun Shu,

Affiliation Department of Molecular Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, United States of America
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Yu Xin,

Affiliation Department of Molecular Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, United States of America
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Chengchao Shou ,

* E-mail: jin.cheng@moffitt.org (JQC); scc@bjcancer.org (CCS)

Affiliation Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, China
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Jin Q. Cheng

* E-mail: jin.cheng@moffitt.org (JQC); scc@bjcancer.org (CCS)

Affiliation Department of Molecular Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida, United States of America
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Phosphorylation
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Transfection
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Non-small cell lung cancer
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Breast cancer
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Immunoprecipitation
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In vitro kinase assay
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Transcription factors
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Apoptosis
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