Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents

• Yini Wang ,

  Contributed equally to this work with: Yini Wang, Dan Gao

  Affiliations Department of Chemistry, Tsinghua University, Beijing, China, The Key Laboratory of Tumor Metabolomics at Shenzhen, Shenzhen, China

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• Dan Gao ,

  Contributed equally to this work with: Yini Wang, Dan Gao

  Affiliations The Key Laboratory of Tumor Metabolomics at Shenzhen, Shenzhen, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

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• Zhe Chen,

  Affiliation The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

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• Shangfu Li,

  Affiliation The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

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• Chunmei Gao,

  Affiliation The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

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• Deliang Cao,

  Affiliation The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

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• Feng Liu,

  Affiliation The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

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• Hongxia Liu ,

  * E-mail: liuhx@sz.tsinghua.edu.cn (HXL); jiangyy@sz.tsinghua.edu.cn (YYJ)

  Affiliations The Key Laboratory of Tumor Metabolomics at Shenzhen, Shenzhen, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China

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• Yuyang Jiang

  * E-mail: liuhx@sz.tsinghua.edu.cn (HXL); jiangyy@sz.tsinghua.edu.cn (YYJ)

  Affiliations The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, School of Medicine, Tsinghua University, Beijing, China

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