Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

Lina Gao; Jacob Schwartzman; Angela Gibbs; Robert Lisac; Richard Kleinschmidt; Beth Wilmot; Daniel Bottomly; Ilsa Coleman; Peter Nelson; Shannon McWeeney; Joshi Alumkal

doi:10.1371/journal.pone.0063563

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Open Access

Peer-reviewed

Research Article

Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

Lina Gao,

Affiliation Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Jacob Schwartzman,

Affiliation Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Angela Gibbs,

Affiliation Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Robert Lisac,

Affiliation Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Richard Kleinschmidt,

Affiliation Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Beth Wilmot,

Affiliations Oregon Clinical and Translational Research Institute, Portland, Oregon, United States of America, Department of Medical Informatics and Clinical Epidemiology; Division of Bioinformatics and Computational Biology; Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Daniel Bottomly,

Affiliations Oregon Clinical and Translational Research Institute, Portland, Oregon, United States of America, Department of Medical Informatics and Clinical Epidemiology; Division of Bioinformatics and Computational Biology; Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Ilsa Coleman,

Affiliation Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
⨯
Peter Nelson,

Affiliation Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United States of America
⨯
Shannon McWeeney,

Affiliations Oregon Clinical and Translational Research Institute, Portland, Oregon, United States of America, Department of Medical Informatics and Clinical Epidemiology; Division of Bioinformatics and Computational Biology; Oregon Health and Science University, Portland, Oregon, United States of America
⨯
Joshi Alumkal

* E-mail: alumkalj@ohsu.edu

Affiliation Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, United States of America
⨯

Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

Lina Gao,
Jacob Schwartzman,
Angela Gibbs,
Robert Lisac,
Richard Kleinschmidt,
Beth Wilmot,
Daniel Bottomly,
Ilsa Coleman,
Peter Nelson,
Shannon McWeeney

Published: May 21, 2013
https://doi.org/10.1371/journal.pone.0063563

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27 May 2013
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Androgen Receptors and Oncogenes may be Activated by Dehydroepiandrosterone (DHEA) Posted by jamesmhoward on 27 May 2013 at 14:03 GMT

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Androgens
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RNA interference
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