Short-Term Genome Stability of Serial Clostridium difficile Ribotype 027 Isolates in an Experimental Gut Model and Recurrent Human Disease

Open Access

Peer-reviewed

Research Article

David W. Eyre ,

* E-mail: david.eyre@ndm.ox.ac.uk

Affiliation NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
⨯
A. Sarah Walker,

Affiliation NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
⨯
Jane Freeman,

Affiliation Leeds Institute of Molecular Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Simon D. Baines,

Affiliation Leeds Institute of Molecular Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Warren N. Fawley,

Affiliation Leeds Institute of Molecular Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
Caroline H. Chilton,

Affiliation Leeds Institute of Molecular Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯
David Griffiths,

Affiliation NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
⨯
Alison Vaughan,

Affiliation NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
⨯
Derrick W. Crook,

Affiliation NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
⨯
Tim E. A. Peto,

Affiliation NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom
⨯
Mark H. Wilcox

Affiliation Leeds Institute of Molecular Medicine, University of Leeds, Leeds, West Yorkshire, United Kingdom
⨯

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Clostridium difficile
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Genomics
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Evolutionary rate
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Antibiotics
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Transcriptional control
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Bacterial spores
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Cytotoxins
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Genome sequencing
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