A Bispecific Protein Capable of Engaging CTLA-4 and MHCII Protects Non-Obese Diabetic Mice from Autoimmune Diabetes

Hongmei Zhao; Jozsef Karman; Ji-Lei Jiang; Jinhua Zhang; Nathan Gumlaw; John Lydon; Qun Zhou; Huawei Qiu; Canwen Jiang; Seng H. Cheng; Yunxiang Zhu

doi:10.1371/journal.pone.0063530

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Open Access

Peer-reviewed

Research Article

A Bispecific Protein Capable of Engaging CTLA-4 and MHCII Protects Non-Obese Diabetic Mice from Autoimmune Diabetes

Hongmei Zhao ,

Contributed equally to this work with: Hongmei Zhao, Jozsef Karman

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Jozsef Karman ,

Contributed equally to this work with: Hongmei Zhao, Jozsef Karman

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Ji-Lei Jiang,

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Jinhua Zhang,

Current address: Livzon Mabpharm, Inc., Guangdong, P. R. China

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Nathan Gumlaw,

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
John Lydon,

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Qun Zhou,

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Huawei Qiu,

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Canwen Jiang,

Current address: Alcon Research, Ltd., Fort Worth, Texas, United States of America

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Seng H. Cheng,

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯
Yunxiang Zhu

* E-mail: yunxiang.zhu@genzyme.com

Affiliation Genzyme, a Sanofi Company, Framingham, Massachusetts, United States of America
⨯

A Bispecific Protein Capable of Engaging CTLA-4 and MHCII Protects Non-Obese Diabetic Mice from Autoimmune Diabetes

Hongmei Zhao,
Jozsef Karman,
Ji-Lei Jiang,
Jinhua Zhang,
Nathan Gumlaw,
John Lydon,
Qun Zhou,
Huawei Qiu,
Canwen Jiang,
Seng H. Cheng

Published: May 21, 2013
https://doi.org/10.1371/journal.pone.0063530

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