Thrombin Has Biphasic Effects on the Nitric Oxide-cGMP Pathway in Endothelial Cells and Contributes to Experimental Pulmonary Hypertension

Open Access

Peer-reviewed

Research Article

Katrin F. Nickel,

Affiliations Cardiology Research, Bayer HealthCare AG, Wuppertal, Germany, Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, Stockholm, Sweden
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Volker Laux,

Affiliation Cardiology Research, Bayer HealthCare AG, Wuppertal, Germany
⨯
Rolf Heumann,

Affiliation Biochemistry II – Molecular Neurobiochemistry, Ruhr-University Bochum, Bochum, Germany
⨯
Georges von Degenfeld

* E-mail: georges.vondegenfeld@bayer.com

Affiliation Common Mechanism Research, Bayer HealthCare AG, Wuppertal, Germany, and Institute for Research in Operative Medicine, University of Witten/Herdecke, Cologne, Germany
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Thrombin
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Endothelial cells
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Pulmonary hypertension
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Pulmonary arteries
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Coagulation factors
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Nitric oxide
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Protease inhibitor therapy
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Protein expression
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