Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements

Saloni Mittal; Matthew Revell; Francesca Barone; Debbie L. Hardie; Gulraj S. Matharu; Alison J. Davenport; Richard A. Martin; Melissa Grant; Frederick Mosselmans; Paul Pynsent; Vaiyapuri P. Sumathi; Owen Addison; Peter A. Revell; Christopher D. Buckley

doi:10.1371/journal.pone.0063470

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Peer-reviewed

Research Article

Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements

Saloni Mittal ,

Contributed equally to this work with: Saloni Mittal, Matthew Revell

Affiliations Rheumatology Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom, Royal Orthopedic Hospital, Birmingham, United Kingdom
⨯
Matthew Revell ,

Contributed equally to this work with: Saloni Mittal, Matthew Revell

Affiliation Royal Orthopedic Hospital, Birmingham, United Kingdom
⨯
Francesca Barone,

Affiliation Rheumatology Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
⨯
Debbie L. Hardie,

Affiliation Rheumatology Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
⨯
Gulraj S. Matharu,

Affiliation Royal Orthopedic Hospital, Birmingham, United Kingdom
⨯
Alison J. Davenport,

Affiliation School of Metallurgy and Materials, University of Birmingham, Birmingham, United Kingdom
⨯
Richard A. Martin,

Affiliation School of Engineering and Applied Sciences & Aston Research Centre for Healthy Ageing, University of Aston, Birmingham, United Kingdom
⨯
Melissa Grant,

Affiliation Biomaterials Unit, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
⨯
Frederick Mosselmans,

Affiliation Diamond Light Source, Harwell Campus, Didcot, United Kingdom
⨯
Paul Pynsent,

Affiliation Royal Orthopedic Hospital, Birmingham, United Kingdom
⨯
Vaiyapuri P. Sumathi,

Affiliation Royal Orthopedic Hospital, Birmingham, United Kingdom
⨯
Owen Addison,

Affiliation Biomaterials Unit, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
⨯
Peter A. Revell ,

¶These authors also contributed equally to this work.

Affiliation Royal Orthopedic Hospital, Birmingham, United Kingdom
⨯
Christopher D. Buckley

* E-mail: c.d.buckley@bham.ac.uk

¶These authors also contributed equally to this work.

Affiliation Rheumatology Research Group, Institute of Biomedical Research, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
⨯

Lymphoid Aggregates That Resemble Tertiary Lymphoid Organs Define a Specific Pathological Subset in Metal-on-Metal Hip Replacements

Saloni Mittal,
Matthew Revell,
Francesca Barone,
Debbie L. Hardie,
Gulraj S. Matharu,
Alison J. Davenport,
Richard A. Martin,
Melissa Grant,
Frederick Mosselmans,
Paul Pynsent

Published: May 28, 2013
https://doi.org/10.1371/journal.pone.0063470

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