TGF-β Signaling Is Often Attenuated during Hepatotumorigenesis, but Is Retained for the Malignancy of Hepatocellular Carcinoma Cells

Xiaoxin Mu; Shu Lin; Junhua Yang; Chen Chen; Yun Chen; Maryanne C. Herzig; Kenneth Washburn; Glenn A. Halff; Christi A. Walter; Beicheng Sun; Lu-Zhe Sun

doi:10.1371/journal.pone.0063436

Loading metrics

Open Access

Peer-reviewed

Research Article

TGF-β Signaling Is Often Attenuated during Hepatotumorigenesis, but Is Retained for the Malignancy of Hepatocellular Carcinoma Cells

Xiaoxin Mu,

Affiliations Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Shu Lin,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Junhua Yang,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Chen Chen,

Affiliation Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Yun Chen,

Affiliation Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Maryanne C. Herzig,

Affiliation Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Kenneth Washburn,

Affiliation Transplant Center, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Glenn A. Halff,

Affiliation Transplant Center, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯
Christi A. Walter,

Affiliations Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Cancer Therapy and Cancer Center, University of Texas Health Science Center, San Antonio, Texas, United States of America, South Texas Veteran’s Health Care System, Audie Murphy Hospital, San Antonio, Texas, United States of America
⨯
Beicheng Sun ,

* E-mail: sunl@uthscsa.edu) (L-ZS; sunbc@njmu.edu.cn (LS) (BS)

Affiliation Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
⨯
Lu-Zhe Sun

* E-mail: sunl@uthscsa.edu) (L-ZS; sunbc@njmu.edu.cn (LS) (BS)

Affiliations Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, United States of America, Cancer Therapy and Cancer Center, University of Texas Health Science Center, San Antonio, Texas, United States of America
⨯

TGF-β Signaling Is Often Attenuated during Hepatotumorigenesis, but Is Retained for the Malignancy of Hepatocellular Carcinoma Cells

Xiaoxin Mu,
Shu Lin,
Junhua Yang,
Chen Chen,
Yun Chen,
Maryanne C. Herzig,
Kenneth Washburn,
Glenn A. Halff,
Christi A. Walter,
Beicheng Sun

Published: May 21, 2013
https://doi.org/10.1371/journal.pone.0063436

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

SMAD signaling
Is the Subject Area "SMAD signaling" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Autocrine signaling
Is the Subject Area "Autocrine signaling" applicable to this article?

Thanks for your feedback.
Metastasis
Is the Subject Area "Metastasis" applicable to this article?

Thanks for your feedback.
Gastrointestinal cancers
Is the Subject Area "Gastrointestinal cancers" applicable to this article?

Thanks for your feedback.
TGF-beta signaling cascade
Is the Subject Area "TGF-beta signaling cascade" applicable to this article?

Thanks for your feedback.