Administration of Bleomycin via the Oropharyngeal Aspiration Route Leads to Sustained Lung Fibrosis in Mice and Rats as Quantified by UTE-MRI and Histology

Open Access

Peer-reviewed

Research Article

Christine Egger,

Affiliations Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland, Biocenter, University of Basel, Basel, Switzerland
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Catherine Cannet,

Affiliation Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Christelle Gérard,

Affiliation Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Elizabeth Jarman,

Affiliation Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Horsham, United Kingdom
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Gabor Jarai,

Affiliation Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Horsham, United Kingdom
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Agnès Feige,

Affiliation Developmental and Molecular Pathways Department, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Thomas Suply,

Affiliation Developmental and Molecular Pathways Department, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Arthur Micard,

Affiliation Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Andrew Dunbar,

Affiliation Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Bruno Tigani,

Affiliation Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Nicolau Beckmann

* E-mail: nicolau.beckmann@novartis.com

Affiliation Global Imaging Group, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Magnetic resonance imaging
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Collagens
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Fibrosis
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Histology
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Pulmonary imaging
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Routes of administration
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Mouse models
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Gene expression
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