Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

Tomoyuki Igawa; Atsuhiko Maeda; Kenta Haraya; Tatsuhiko Tachibana; Yuki Iwayanagi; Futa Mimoto; Yoshinobu Higuchi; Shinya Ishii; Shigero Tamba; Naoka Hironiwa; Kozue Nagano; Tetsuya Wakabayashi; Hiroyuki Tsunoda; Kunihiro Hattori

doi:10.1371/journal.pone.0063236

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Open Access

Peer-reviewed

Research Article

Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

Tomoyuki Igawa ,

* E-mail: igawatmy@chugai-pharm.co.jp

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Atsuhiko Maeda,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Kenta Haraya,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Tatsuhiko Tachibana,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Yuki Iwayanagi,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Futa Mimoto,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Yoshinobu Higuchi,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Shinya Ishii,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Shigero Tamba,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Naoka Hironiwa,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Kozue Nagano,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Tetsuya Wakabayashi,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Hiroyuki Tsunoda,

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯
Kunihiro Hattori

Affiliation Research Division, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
⨯

Engineered Monoclonal Antibody with Novel Antigen-Sweeping Activity In Vivo

Tomoyuki Igawa,
Atsuhiko Maeda,
Kenta Haraya,
Tatsuhiko Tachibana,
Yuki Iwayanagi,
Futa Mimoto,
Yoshinobu Higuchi,
Shinya Ishii,
Shigero Tamba,
Naoka Hironiwa

Published: May 7, 2013
https://doi.org/10.1371/journal.pone.0063236

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Enzyme-linked immunoassays
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Adjustment of dosage at steady state
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Protein engineering
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Antigenic variation
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Cell binding
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