Activating Mutations in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhance Reactive Oxygen Species Production That Contributes to Myeloproliferative Disorder

Open Access

Peer-reviewed

Research Article

Dan Xu ,

Contributed equally to this work with: Dan Xu, Hong Zheng

Affiliation Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Hong Zheng ,

Contributed equally to this work with: Dan Xu, Hong Zheng

Affiliation Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Wen-Mei Yu,

Affiliation Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Cheng-Kui Qu

* E-mail: cxq6@case.edu

Affiliation Department of Medicine, Division of Hematology and Oncology, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, United States of America
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Mitochondria
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Bone marrow cells
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Cytokines
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Macrophages
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Oxygen consumption
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Cytokine therapy
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Deletion mutation
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Reactive oxygen species
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