Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

• Francesca Gugliesi ,

  Contributed equally to this work with: Francesca Gugliesi, Mandar Bawadekar

  Affiliation Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy

  ⨯
• Mandar Bawadekar ,

  Contributed equally to this work with: Francesca Gugliesi, Mandar Bawadekar

  Affiliations Department of Translational Medicine, University of Piemonte Orientale “Amedeo Avogadro”, Medical School, Novara, Italy, Interdisciplinary Research Center of Autoimmune Diseases, Department of Translational Medicine, University of Piemonte Orientale “Amedeo Avogadro”, Medical School, Novara, Italy

  ⨯
• Marco De Andrea,

  Affiliations Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy, Department of Translational Medicine, University of Piemonte Orientale “Amedeo Avogadro”, Medical School, Novara, Italy

  ⨯
• Valentina Dell’Oste,

  Affiliation Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy

  ⨯
• Valeria Caneparo,

  Affiliations Department of Translational Medicine, University of Piemonte Orientale “Amedeo Avogadro”, Medical School, Novara, Italy, Interdisciplinary Research Center of Autoimmune Diseases, Department of Translational Medicine, University of Piemonte Orientale “Amedeo Avogadro”, Medical School, Novara, Italy

  ⨯
• Angela Tincani,

  Affiliation Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy

  ⨯
• Marisa Gariglio,

  Affiliations Department of Translational Medicine, University of Piemonte Orientale “Amedeo Avogadro”, Medical School, Novara, Italy, Interdisciplinary Research Center of Autoimmune Diseases, Department of Translational Medicine, University of Piemonte Orientale “Amedeo Avogadro”, Medical School, Novara, Italy

  ⨯
• Santo Landolfo

  * E-mail: santo.landolfo@unito.it

  Affiliation Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy

  ⨯