A Cell-Permeant Amiloride Derivative Induces Caspase-Independent, AIF-Mediated Programmed Necrotic Death of Breast Cancer Cells

Open Access

Peer-reviewed

Research Article

Leonardo J. Leon,

Affiliations Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, California, United States of America, UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, United States of America
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Nagarekha Pasupuleti,

Affiliation Department of Neurology, UC Davis School of Medicine, Sacramento, California, United States of America
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Fredric Gorin,

Affiliations Department of Neurology, UC Davis School of Medicine, Sacramento, California, United States of America, UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, United States of America
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Kermit L. Carraway III

* E-mail: klcarraway@ucdavis.edu

Affiliations Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, California, United States of America, UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California, United States of America
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Necrotic cell death
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Apoptosis
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Breast cancer
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Cytotoxicity
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Autophagic cell death
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Cancer treatment
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Necrosis
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Cell death
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