The Progestin-Only Contraceptive Medroxyprogesterone Acetate, but Not Norethisterone Acetate, Enhances HIV-1 Vpr-Mediated Apoptosis in Human CD4+ T Cells through the Glucocorticoid Receptor

Open Access

Peer-reviewed

Research Article

The Progestin-Only Contraceptive Medroxyprogesterone Acetate, but Not Norethisterone Acetate, Enhances HIV-1 Vpr-Mediated Apoptosis in Human CD4⁺ T Cells through the Glucocorticoid Receptor

Michele Tomasicchio,

Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, Western Province, South Africa
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Chanel Avenant,

Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, Western Province, South Africa
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Andrea Du Toit,

Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, Western Province, South Africa
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Roslyn M. Ray,

Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, Western Province, South Africa
⨯
Janet P. Hapgood

* E-mail: Janet.Hapgood@uct.ac.za

Affiliation Department of Molecular and Cell Biology, University of Cape Town, Cape Town, Western Province, South Africa
⨯

Apoptosis
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T cells
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HIV-1
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Steroids
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Female contraception
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Gene regulation
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T cell receptors
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Polymerase chain reaction
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