IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Atsuhiro Matsumoto; Takanori Kanai; Yohei Mikami; Po–Sung Chu; Nobuhiro Nakamoto; Hirotoshi Ebinuma; Hidetsugu Saito; Toshiro Sato; Hideo Yagita; Toshifumi Hibi

doi:10.1371/journal.pone.0062853

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Open Access

Peer-reviewed

Research Article

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Atsuhiro Matsumoto,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯
Takanori Kanai ,

* E-mail: takagast@sc.itc.keio.ac.jp (TK); thibi@sc.itc.keio.ac.jp (TH)

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯
Yohei Mikami,

Affiliations Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
⨯
Po–Sung Chu,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯
Nobuhiro Nakamoto,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯
Hirotoshi Ebinuma,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯
Hidetsugu Saito,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯
Toshiro Sato,

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯
Hideo Yagita,

Affiliation Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
⨯
Toshifumi Hibi

* E-mail: takagast@sc.itc.keio.ac.jp (TK); thibi@sc.itc.keio.ac.jp (TH)

Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
⨯

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Atsuhiro Matsumoto,
Takanori Kanai,
Yohei Mikami,
Po–Sung Chu,
Nobuhiro Nakamoto,
Hirotoshi Ebinuma,
Hidetsugu Saito,
Toshiro Sato,
Hideo Yagita,
Toshifumi Hibi

Published: April 23, 2013
https://doi.org/10.1371/journal.pone.0062853

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