Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding

• Alfred Lammens,

  Current address: Proteros biostructures GmbH, Martinsried, Germany

  Affiliations Center for Integrated Protein Science (CIPSM), Munich, Germany, Department of Biochemistry at the Gene Center, Ludwig-Maximilians University, Munich, Germany

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• Monika Baehner,

  Affiliation Biologics Research, Roche Pharma Research and Early Development (pRED), Penzberg, Germany

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• Ulrich Kohnert,

  Affiliation Biologics Research, Roche Pharma Research and Early Development (pRED), Penzberg, Germany

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• Jens Niewoehner,

  Affiliation Biologics Research, Roche Pharma Research and Early Development (pRED), Penzberg, Germany

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• Leopold von Proff,

  Affiliation Research and Development, Roche Professional Diagnostics, Penzberg, Germany

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• Michael Schraeml,

  Affiliation Research and Development, Roche Professional Diagnostics, Penzberg, Germany

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• Katja Lammens,

  Affiliation Department of Biochemistry at the Gene Center, Ludwig-Maximilians University, Munich, Germany

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• Karl-Peter Hopfner

  * E-mail: hopfner@lmb.uni-muenchen.de

  Affiliations Center for Integrated Protein Science (CIPSM), Munich, Germany, Department of Biochemistry at the Gene Center, Ludwig-Maximilians University, Munich, Germany

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