Profiling the Secretion of Soluble Mediators by End Stage Osteoarthritis Synovial Tissue Explants Reveals a Reduced Responsiveness to an Inflammatory Trigger

• Lobke M. Gierman,

  Affiliations TNO, Leiden, The Netherlands, Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Benno van El,

  Affiliation TNO, Leiden, The Netherlands

  ⨯
• Frits van der Ham,

  Affiliation TNO, Leiden, The Netherlands

  ⨯
• Angela Koudijs,

  Affiliation TNO, Leiden, The Netherlands

  ⨯
• Reinout Stoop,

  Affiliation TNO, Leiden, The Netherlands

  ⨯
• Jan H. Verheijen,

  Affiliation TNO, Leiden, The Netherlands

  ⨯
• Margreet Kloppenburg,

  Affiliation Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Gerjo J. V. M. van Osch,

  Affiliation Department of Orthopaedics and Department of Otorhinolaryngology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

  ⨯
• Vedrana Stojanovic-Susulic,

  Affiliation Pharmaceutical R&D, Janssen, A division of Johnson & Johnson, Malvern, Pennsylvania, United States of America

  ⨯
• Tom W. J. Huizinga,

  Affiliation Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Anne-Marie Zuurmond

  * E-mail: Anne-Marie.Zuurmond@tno.nl

  Affiliation TNO, Leiden, The Netherlands

  ⨯