The Stimulatory Adenosine Receptor ADORA2B Regulates Serotonin (5-HT) Synthesis and Release in Oxygen-Depleted EC Cells in Inflammatory Bowel Disease

Open Access

Peer-reviewed

Research Article

Rikard Damen ,

Contributed equally to this work with: Rikard Damen, Martin Haugen

Affiliation Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Martin Haugen ,

Contributed equally to this work with: Rikard Damen, Martin Haugen

Affiliation Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Bernhard Svejda,

Affiliation Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, United States of America
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Daniele Alaimo,

Affiliation Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, United States of America
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Oystein Brenna,

Affiliation Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
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Roswitha Pfragner,

Affiliation Institute of Pathophysiology and Immunology, Centre for Molecular Medicine, Graz, Austria
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Bjorn I. Gustafsson,

Affiliation Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
⨯
Mark Kidd

* E-mail: mark.kidd@yale.edu

Affiliation Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut, United States of America
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Hypoxia
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Adenosine
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Secretion
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Serotonin
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Signal amplification
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MAPK signaling cascades
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Colitis
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Inflammatory bowel disease
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