Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder

James J. Valdés; Alexandra Schwarz; Israel Cabeza de Vaca; Eric Calvo; Joao H. F. Pedra; Victor Guallar; Michalis Kotsyfakis

doi:10.1371/journal.pone.0062562

Loading metrics

Open Access

Peer-reviewed

Research Article

Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder

James J. Valdés ,

* E-mail: valdjj@gmail.com

Affiliation Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, České Budějovice, Czech Republic
⨯
Alexandra Schwarz,

Affiliation Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, České Budějovice, Czech Republic
⨯
Israel Cabeza de Vaca,

Affiliations Joint Barcelona Supercomputing Center-Institute for Research in Biomedicine (BSC-IRB) Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
⨯
Eric Calvo,

Affiliation Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Joao H. F. Pedra,

Affiliation Center for Disease Vector Research and Department of Entomology, University of California Riverside, Riverside, California, United States of America
⨯
Victor Guallar ,

Contributed equally to this work with: Victor Guallar, Michalis Kotsyfakis

Affiliations Joint Barcelona Supercomputing Center-Institute for Research in Biomedicine (BSC-IRB) Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
⨯
Michalis Kotsyfakis

Contributed equally to this work with: Victor Guallar, Michalis Kotsyfakis

Affiliation Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, České Budějovice, Czech Republic
⨯

Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder

James J. Valdés,
Alexandra Schwarz,
Israel Cabeza de Vaca,
Eric Calvo,
Joao H. F. Pedra,
Victor Guallar,
Michalis Kotsyfakis

Published: May 3, 2013
https://doi.org/10.1371/journal.pone.0062562

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Serine proteases
Is the Subject Area "Serine proteases" applicable to this article?

Thanks for your feedback.
Enzyme inhibitors
Is the Subject Area "Enzyme inhibitors" applicable to this article?

Thanks for your feedback.
Sequence alignment
Is the Subject Area "Sequence alignment" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Protease inhibitors
Is the Subject Area "Protease inhibitors" applicable to this article?

Thanks for your feedback.
Molecular dynamics
Is the Subject Area "Molecular dynamics" applicable to this article?

Thanks for your feedback.
Protein structure prediction
Is the Subject Area "Protein structure prediction" applicable to this article?

Thanks for your feedback.
Sequence motif analysis
Is the Subject Area "Sequence motif analysis" applicable to this article?

Thanks for your feedback.