Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB Signaling Pathway and an NLRP3 Inflammasome Activation

Lenka Palová-Jelínková; Klára Dáňová; Hana Drašarová; Miloš Dvořák; David P. Funda; Petra Fundová; Anna Kotrbová-Kozak; Marie Černá; Jana Kamanová; Stefan F. Martin; Marina Freudenberg; Ludmila Tučková

doi:10.1371/journal.pone.0062426

Loading metrics

Open Access

Peer-reviewed

Research Article

Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB Signaling Pathway and an NLRP3 Inflammasome Activation

Lenka Palová-Jelínková ,

* E-mail: lenicka@biomed.cas.cz

Affiliation Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Klára Dáňová,

Affiliation Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Hana Drašarová,

Affiliation Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Miloš Dvořák,

Affiliation 1st Medical Faculty, Charles University, Prague, Czech Republic
⨯
David P. Funda,

Affiliation Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Petra Fundová,

Affiliation Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Anna Kotrbová-Kozak,

Affiliation Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Marie Černá,

Affiliation Third Faculty of Medicine, Charles University, Prague, Czech Republic
⨯
Jana Kamanová,

Affiliation Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯
Stefan F. Martin,

Affiliation Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
⨯
Marina Freudenberg,

Affiliation Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany
⨯
Ludmila Tučková

Affiliation Institute of Microbiology, Department of Immunology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⨯

Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB Signaling Pathway and an NLRP3 Inflammasome Activation

Lenka Palová-Jelínková,
Klára Dáňová,
Hana Drašarová,
Miloš Dvořák,
David P. Funda,
Petra Fundová,
Anna Kotrbová-Kozak,
Marie Černá,
Jana Kamanová,
Stefan F. Martin

Published: April 29, 2013
https://doi.org/10.1371/journal.pone.0062426

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Secretion
Is the Subject Area "Secretion" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
Immune receptor signaling
Is the Subject Area "Immune receptor signaling" applicable to this article?

Thanks for your feedback.
Inflammasomes
Is the Subject Area "Inflammasomes" applicable to this article?

Thanks for your feedback.
Wheat
Is the Subject Area "Wheat" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.