Dynamic and Static Overloading Induce Early Degenerative Processes in Caprine Lumbar Intervertebral Discs

Cornelis P. L. Paul; Tom Schoorl; Hendrik A. Zuiderbaan; Behrouz Zandieh Doulabi; Albert J. van der Veen; Peter M. van de Ven; Theo H. Smit; Barend J. van Royen; Marco N. Helder; Margriet G. Mullender

doi:10.1371/journal.pone.0062411

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Open Access

Peer-reviewed

Research Article

Dynamic and Static Overloading Induce Early Degenerative Processes in Caprine Lumbar Intervertebral Discs

Cornelis P. L. Paul,

Affiliations Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Amsterdam, The Netherlands
⨯
Tom Schoorl,

Affiliation Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Hendrik A. Zuiderbaan,

Affiliation Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯
Behrouz Zandieh Doulabi,

Affiliation Department of Oral Cell Biology, Academic Centre of Dentistry Amsterdam, Amsterdam, The Netherlands
⨯
Albert J. van der Veen,

Affiliations Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Peter M. van de Ven,

Affiliation Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
⨯
Theo H. Smit,

Affiliations Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Barend J. van Royen,

Affiliations Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Marco N. Helder,

Affiliations Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Skeletal Tissue Engineering Group Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
⨯
Margriet G. Mullender

* E-mail: m.mullender@vumc.nl

Affiliations Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands, Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Amsterdam, The Netherlands, Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands
⨯

Dynamic and Static Overloading Induce Early Degenerative Processes in Caprine Lumbar Intervertebral Discs

Cornelis P. L. Paul,
Tom Schoorl,
Hendrik A. Zuiderbaan,
Behrouz Zandieh Doulabi,
Albert J. van der Veen,
Peter M. van de Ven,
Theo H. Smit,
Barend J. van Royen,
Marco N. Helder,
Margriet G. Mullender

Published: April 30, 2013
https://doi.org/10.1371/journal.pone.0062411

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