A Cryptic Targeting Signal Creates a Mitochondrial FEN1 Isoform with Tailed R-Loop Binding Properties

Open Access

Peer-reviewed

Research Article

Lawrence Kazak,

Current address: Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Aurelio Reyes,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Jiuya He,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Stuart R. Wood,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Gloria Brea-Calvo,

Affiliation MRC-Mitochondrial Biology Unit, Wellcome Trust-MRC Building, Cambridge, United Kingdom
⨯
Torgeir T. Holen,

Affiliation Institute of Basic Medical Sciences, Oslo, Norway
⨯
Ian J. Holt

* E-mail: iholt@nimr.mrc.ac.uk

Affiliation MRC-National Institute for Medical Research, Mill Hill, London, United Kingdom
⨯

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Mitochondria
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Mitochondrial DNA
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Immunoblotting
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DNA replication
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DNA-binding proteins
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RNA structure
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DNA-RNA hybridization
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RNA hybridization
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