Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

Maarten van Dinther; Juan Zhang; Stella E. Weidauer; Verena Boschert; Eva-Maria Muth; Achim Knappik; David J. J. de Gorter; Puck B. van Kasteren; Christian Frisch; Thomas D. Mueller; Peter ten Dijke

doi:10.1371/journal.pone.0062295

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Open Access

Peer-reviewed

Research Article

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

Maarten van Dinther,

Affiliation Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Juan Zhang,

Affiliation Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Stella E. Weidauer,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institut, Wuerzburg, Germany
⨯
Verena Boschert,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institut, Wuerzburg, Germany
⨯
Eva-Maria Muth,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institut, Wuerzburg, Germany
⨯
Achim Knappik,

Affiliation AbD Serotec, a Bio-Rad company, Puchheim, Germany
⨯
David J. J. de Gorter,

Affiliation Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Puck B. van Kasteren,

Current address: Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

Affiliation Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Christian Frisch,

Affiliation AbD Serotec, a Bio-Rad company, Puchheim, Germany
⨯
Thomas D. Mueller,

Affiliation Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs Institut, Wuerzburg, Germany
⨯
Peter ten Dijke

* E-mail: P.ten_Dijke@lumc.nl

Affiliation Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling

Maarten van Dinther,
Juan Zhang,
Stella E. Weidauer,
Verena Boschert,
Eva-Maria Muth,
Achim Knappik,
David J. J. de Gorter,
Puck B. van Kasteren,
Christian Frisch,
Thomas D. Mueller

Published: April 29, 2013
https://doi.org/10.1371/journal.pone.0062295

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Cell binding
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Recombinant proteins
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Wnt signaling cascade
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Immunoprecipitation
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Transfection
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Osteoporosis
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