A Phenylalanine to Serine Substitution within an O-Protein Mannosyltransferase Led to Strong Resistance to PMT-Inhibitors in Pichia pastoris

Open Access

Peer-reviewed

Research Article

Rebecca Argyros,

Affiliation GlycoFi Inc., a wholly-owned subsidiary of Merck & Co. Inc., Lebanon, New Hampshire, United States of America
⨯
Stephanie Nelson,

Affiliation GlycoFi Inc., a wholly-owned subsidiary of Merck & Co. Inc., Lebanon, New Hampshire, United States of America
⨯
Angela Kull,

Affiliation GlycoFi Inc., a wholly-owned subsidiary of Merck & Co. Inc., Lebanon, New Hampshire, United States of America
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Ming-Tang Chen,

Affiliation GlycoFi Inc., a wholly-owned subsidiary of Merck & Co. Inc., Lebanon, New Hampshire, United States of America
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Terrance A. Stadheim,

Affiliation GlycoFi Inc., a wholly-owned subsidiary of Merck & Co. Inc., Lebanon, New Hampshire, United States of America
⨯
Bo Jiang

* E-mail: bo_jiang@merck.com

Affiliation GlycoFi Inc., a wholly-owned subsidiary of Merck & Co. Inc., Lebanon, New Hampshire, United States of America
⨯

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Point mutation
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Pichia pastoris
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Yeast
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Saccharomyces cerevisiae
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Candida albicans
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Enzyme inhibitors
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Mannose
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Endoplasmic reticulum
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