Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs

Open Access

Peer-reviewed

Research Article

Jakyung Yoo,

Affiliation National Leading Research Lab of Molecular Modeling & Drug Design, College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Global Top5 Research Program, Ewha Womans University, Seoul, Korea
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Sun Choi ,

* E-mail: sunchoi@ewha.ac.kr (SC) (SC); jose.medina.franco@gmail.com (JLMF) (JM)

Affiliation National Leading Research Lab of Molecular Modeling & Drug Design, College of Pharmacy, Division of Life and Pharmaceutical Sciences, and Global Top5 Research Program, Ewha Womans University, Seoul, Korea
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José L. Medina-Franco

* E-mail: sunchoi@ewha.ac.kr (SC) (SC); jose.medina.franco@gmail.com (JLMF) (JM)

Affiliation Instituto de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico
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DNA methylation
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Crystal structure
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Hydrogen bonding
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Carbon
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Biochemical cofactors
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Protein structure
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Pyrimidines
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Methyltransferases
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